New enzyme target for selective cancer therapies
Researchers at the University of Alberta have developed a compound that targets a specific enzyme that’s prominent in certain cancers. The team synthesized a unique inhibitor that prevents the activity of an enzyme called neuraminidase. Neuraminidases are found in surplus amounts in glioblastoma cells, a form of brain cancer.
Search for brain tumor biomarkers in urine is successful
A biomarker’s levels go up or down as the patient’s disease gets better or worsens. In a recent study two researchers have found a prominent relationship between urine netrin levels and medulloblastoma, the most common malignant brain tumor of children.
Tailoring tumor treatment for each child
Childhood brain tumors that relapse have a poor outcome. At last month’s Worldwide Innovative Networking 2014 Symposium in Paris, Dr. Stefan Pfister shared the early successes of INFORM, a registry for individualizing treatment in pediatric brain tumor patients. Using biopsies, doctors treat relapsed tumors with targeted drugs rather than generalized chemotherapy.
Growing body of literature points to “epigenetic addiction”
Epigenetic addiction, an aberrant epigenetic state to which a tumor is addicted, has been recently determined as a previously unsuspected mechanism of oncogenesis.
Podcast addresses innovative childhood cancer research news
Research presented at the American Society of Clinical Oncology’s annual meeting is the topic of a podcast with a St. Jude Children’s Research Hospital oncologist. Dr. Melissa Hudson discusses a clinical study of a monoclonal antibody in DIPG, a study of chemotherapy-induced hearing loss, and a study of the late effects of treatment on sperm count in adult survivors of childhood cancer.
Autopsy-based protocol investigates DIPG spectrums
Diffuse intrinsic pontine glioma is one of the deadliest forms of childhood brain tumors. Findings of a study using a newly-developed autopsy-based protocol suggest that classic DIPGs actually represent a diverse histologic spectrum and that the current grading scheme may not accurately predict outcome.
Study links parents’ chemical exposure to brain tumors in children
study at the University of Western Australia compared the occupational exposures to certain chemicals among parents of children with brain tumors with those of parents whose children did not have brain tumors. Men exposed in the year before their child was conceived and women exposed at any time in their life have a higher risk of their child developing a brain tumor.
Promising non-invasive imaging technique developed
The Institute of Cancer Research in London has developed a non-invasive way to monitor brain tumor drugs used on children. Test results could potentially be used to assess the impact of treatment with a new generation of drugs, and thereby potentially accelerate progress toward higher survival rates for pediatric brain tumor patients. The new technology focuses on evaluating treatments for glioblastoma, one of the most difficult types of brain tumors to treat.
Cancer community concerned about EU proposal
A recent European Parliament resolution may impose that researchers be required to ask for a patient's ‘specific’ consent each time new research is carried out on already available data and/or tissues. The unintended consequence of the wording may put at stake the practice of retrospective clinical research, tissue banking and population-based cancer registries.
Reproductive consequences for curing childhood cancer
Although the number of childhood cancer survivors is increasing and many grow up to live healthy lives, cancer treatments can take away an important choice in adulthood. – Pacific Standard
Failure to adopt a healthy lifestyle increases risk of metabolic syndrome in childhood cancer survivors
A recent St. Jude Lifetime Cohort Study that included childhood cancer survivors of various cancers as participants found that survivors who fail to maintain a heart-healthy lifestyle more than double their risk of developing metabolic syndrome. -The ASCO Post
Childhood cancer survivors face more health issues in adulthood
According to a federally funded study led by researchers at St. Jude Children's Research Hospital, adult survivors of childhood cancer face significant health problems as they age. The study shows that these survivors are five times more likely than their siblings to develop new cancers beyond the age of 35. –Science Daily
Parents donate child’s tumor tissue to research
After losing their 6-year-old son to DIPG, parents Lenore and Trevor Wyant donated his tumor tissue to research, hoping to find answers for other children battling the disease. Because of donated tissue samples, scientists were able to conduct the studies that led to the discovery reported in 2012, that unique genetic mutations are present in 80 percent of DIPG samples. –USA Today