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Research News


New study examines modified Atkins diet for malignant glioma patients
Investigators report on the effects a modified Atkins diet on malignant glioma in a small group of adult patients. – Oxford Journals


Medulloblastomas now classified before surgery
Researchers at Children's Hospital Los Angeles have determined that the four subgroups of medulloblastoma can be recognized at diagnosis using imaging. – EurekAlert!


Spotlight: California-based scientists experience immunotherapy breakthrough outside of lab
Meet Dr. Dan Chen and Dr. Ira Mellman, two accomplished scientists who experienced a “eureka” moment outside of the lab. Their conceptual breakthrough – named the Cancer-Immunity Cycle, has become an intellectual framework for cancer immunotherapy research. – Genentech


Gender influences survival after childhood brain tumor diagnosis
A study shows that girls diagnosed with pediatric brain tumors are likely to live six years longer than boys diagnosed with the disease. The study examined 97 patients — 43 females and 54 males —21 or younger, who were diagnosed with a high-grade glioma. – Weill Cornell Medical College


Ion channel blockers may be useful in cancer therapy
Scientists from the University of California, San Francisco have found that potassium ion channels may be useful targets in cancer therapy. Their preclinical findings led to the unconventional use of an ion channel blocker in a patient with refractory metastatic medulloblastoma. – Medical Xpress


Agenus announces data on vaccine in GBM patients
Agenus Inc. reported its vaccine, Prophage, proved to be effective in achieving overall survival of 24 months in adult patients with newly diagnosed glioblastoma multiforme (GBM) when added to standard treatment. A correlation was found between the level of PD-L1 expression – a biomarker on white blood cells - and response to treatment. – Agenus


PBTF helps conduct study that examines potential years of life lost in young brain tumor patients
In the realm of childhood cancers, incidence and survival rates are commonly reported statistics, but these may fail to capture the full impact of the disease. In a new study, researchers, including PBTF’s vice president of research, describe the years of potential life lost and years of life lived with disease in children and adolescents who died of cancer in the United States. – Cancer Medicine Journal


Cancer community concerned about EU proposal
A recent European Parliament resolution may impose that researchers be required to ask for a patient's ‘specific’ consent each time new research is carried out on already available data and/or tissues. The unintended consequence of the wording may put at stake the practice of retrospective clinical research, tissue banking and population-based cancer registries.


Parents donate child’s tumor tissue to research
After losing their 6-year-old son to DIPG, parents Lenore and Trevor Wyant donated his tumor tissue to research, hoping to find answers for other children battling the disease. Because of donated tissue samples, scientists were able to conduct the studies that led to the discovery reported in 2012, that unique genetic mutations are present in 80 percent of DIPG samples. –USA Today


Childhood cancer survivors face more health issues in adulthood
According to a federally funded study led by researchers at St. Jude Children's Research Hospital, adult survivors of childhood cancer face significant health problems as they age. The study shows that these survivors are five times more likely than their siblings to develop new cancers beyond the age of 35. –Science Daily