PBTF-sponsored research 2010-present
Batinic-Haberle, I., Reboucas JS, Benov L, Spasojevic I, Chemistry, biology and medical effects of water-soluble porphyrins, in 13-volume Handbook of Porphyrin Science, Kadish KM, Smith KM, Guillard R, EDs.; vol11, World Scientific
Batinic-Haberle, I., Reboucas, J. S., Spasojevic, I. Superoxide dismutase mimics: Chemistry, Pharmacology, and Therapeudic Potential. Invited Comprehensive Review, Antioxid Redox Signaling 2010, 13:877-918, PMID: 20095865, PMID: 21616142.
Kongkham PN, Onvani S, Smith CA, Rutka JT. Inhibition of the MET Receptor Tyrosine Kinase as a Novel Therapeutic Strategy in Medulloblastoma. Transl Oncol. 2010 Dec 1;3(6):336-43.
Gustafson WC, Weiss WA. Addiction to B-MYB. Oncotarget 1:235-6, 2011
Faria CM, Rutka JT, Smith C, Kongkham P. Epigenetic mechanisms regulating neural development and pediatric brain tumor formation. Journal of Neurosurgery: Pediatrics. 2011 Aug;8(2):119-32.
Bakthavatchalu, V., Dey, S., Xu, Y., Noel, T., Jungsuwadee, P., Holley, A. K., Dhar, S. K., Batinic-Haberle, I., St. Clari, D. K., Manganese Superoxide dismutaseis a mitochondrial fidelity protein that protects Poly against UV-induced inactivation, Oncogene, 2011, doi: 10.1038/onc.2011.407. PMID 21909133.
A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin combines superb potency and lipophilicity with low toxicity, Rajic, Z., Tovmasyan, A., Spasojevic, I., Sheng, H., Lu, M., Gralla, E.B., Warner, D. S., Benov, L., Batinic-Haberle, I., Free Radic Biol Med, 2011, doi: 10.1016/j.freeradbiomed.2012.02.006, PMID: 22336516.
Amaravadi RK, Lippincott-Schwartz J, Yi X-M, Weiss WA, Takebe N, Timmer W, DePaolo RS, Lotze M, White E. Principles and current strategies for targeting autophagy for cancer treatment. Clinical Cancer Research 17:654-666, 2011
Nicolaides TP, Li H, Solomon DA, Hariono S, Hashizume R, Barkovich K, Baker SJ, Paugh BS, Jones C, Forshew T, Hindley GF, Hodgson JG, Kim J-S, Rowitch DH, Weiss WA, Waldman TA, James CD. Targeted Therapy for BRAFV600E Malignant Astrocytoma. Clinical Cancer Research 17:7595-604, 2011
Schwalbe EC, Lindsey JC, Straughton D, Hogg TL, Cole M, Megahed H, Ryan SL, Lusker ME, Taylor MD, Gilbertson RJ, Ellison DW, Baily S, Clifford SC. Rapid diagnosis of medulloblastoma molecular subgroups. Clinical Cancer Research 2011. 17(7). 1883-1894
Mehta S, Huillard E, Kesari S, Maire CL, Golebiowski D, Harrington EP, Alberta JA, Kane MF, Theisen M, Ligon KL, Rowitch DH, Stiles CD. The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell 19(3):359-71, 2011
Remke M, Hielscher T, Northcott PA, Witt H, Ryzhova M, Wittmann A, Benner A, von Deimling A, Scheurlen W, Perry A, Croul S, Kulozik AE, Lichter P, Taylor MD, Pfister SM, Korshunov A. Adult Medulloblastoma Comprises Three Major Molecular Variants. Journal of Clinical Oncology, 2011. 19 (2717-2723)
Hendrik Witt, Stephen C. Mack, Marina Ryzhova, Sebastian Bender, Martin Sill, Ruth Isserlin, Axel Benner, Thomas Hielscher, Till Milde, Marc Remke, David T. Jones, Paul A. Northcott, Stephen S. Roberts, Luca Massimi, Tim van Meter, William A. Weiss, Nalin Gupta, Wiesia Grajkowska, Boleslaw Lach, Jae Y. Cho, Andreas von Deimling, Andreas E. Kulozik, Olaf Witt, Gary D. Bader, Abhijit Guha, James T. Rutka, Peter Lichter, Andrey Korshunov, Michael D. Taylor*, Stefan M. Pfister*. 2011. Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma. Cancer Cell 2011. (20): 143-157.
Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, Benner A, Hielscher T, Milde T, Remke M, Jones DT, Northcott PA, Garzia L, Bertrand KC, Wittmann A, Yao Y, Roberts SS, Massimi L, Van Meter T, Weiss WA, Gupta N, Grajkowska W, Lach B, Cho YJ, von Deimling A, Kulozik AE, Witt O, Bader GD, Hawkins CE, Tabori U, Guha A, Rutka JT, Lichter P, Korshunov A, Taylor MD, Pfister SM. Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell 20:143-157, 2011
Manganese superoxide dismutase, MnSOD and its mimics, Miriyala, S., Tovmasyan, A., Spasojevic, I., Salvemini, D., Vujaskovic, Z., St. Clair, D. K., Batinic-Haberle, I., Biochim. Biophys Acta, 2011, invited review doi: 10.1016/j.bbadis.2011.12.002, PMID: 22198225.
Pazhanisamy S. K., Li, H., Batinic-Haberle, I., Zhou, D., NADPH oxidase inhibition attenuates total body-irradiation-induced hematopoietic genomic instability, Mutagenesis, 2011, 26, 431-435. PMID: 21415439.
Bertrand KC, Mack SC, Northcott PA, Garzia L, Dubuc AM, Taylor MD. Epigenetic and genetic perturbation identifies PCDH10 as a candidate tumour suppressor gene in medulloblastoma. Child’s Nervous System 2011. 27(8); 1243-9
Paul A. Northcott, Andrey Korshunov, Hendrik Witt, Thomas Hielscher, Charles Eberhart, Stephen Mack, Eric Bouffet, Steven C. Clifford, Cynthia Hawkins, Pim French, James T. Rutka, Stefan Pfister, and Michael D. Taylor. Medulloblastoma Comprises Four Distinct Diseases. Journal of Clinical Oncology. 2011. Vol 29: 1408-1414
Batinic-Haberle, I., Rajic, Z., Tovmasyan, A., Reboucas, J. S., Ye, X., Leong, K. W., Dewhirst, M. W., Vujaskovic, Z., Benov, L., Spasojevic, I. Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics Free Radic Biol Med, invited review, 2011, 51. 1035-1053. PMID: 21616142
Li, H. Wang Y., Senthil K. Pazhanisamy, S. K., Shao, L., Batinic-Haberle, I., Meng, A., Zhou, D., Mn(III) meso-tetrakis (N-ethylpyridinium-2-yl) porphyrin (MnTE-2-PyP5+) mitigates total body irradiation-induced long-term bone marrow suppression, Free Radic Biol Med, 2011, 51:30-37, PMID: 21565268.
Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien AC, Fu H, Petryniak MA, Potter GB, Liu Z, Powers JF, Runquist IS, Rowitch DH, Stiles CD. Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron 69(5):906-17, 2011
Otero JJ, Rowitch DH, Vandenberg S. OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms. J Neurooncol 104(2):423-38, 2011
Monje M, Mitra SS, Freret ME, Raveh TB, Kim J, Masek M, Attema JL, Li G, Haddix T, Edwards MS, Fisher PG, Weissman IL, Rowitch DH, Vogel H, Wong AJ, Beachy PA. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. PNAS 108(11):4453-8, 2011
Northcott PA, Hielscher T, Dubuc A, Mack S, Shih D, Remke M, Al-Halabi H, Albrecht S, Jabado N, Eberhart CG, Grajkowska W, Weiss WA, Clifford SC, Bouffet E, Rutka JT, Korshunov A, Pfister S, Taylor MD. Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathol 122:231-40, 2011
Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z. Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma. J Clin Investigation 122(3):911-22, 2011
Korshunov A, Remke M, Kool M, Hielscher T, Northcott PA, Williamson D, Pfaff E, Witt H, Jones DT, Ryzhova M, Cho YJ, Wittmann A, Benner A, Weiss WA, von Deimling A, Scheurlen W, Kulozik AE, Clifford SC, Collins VP, Westermann F, Taylor MD, Lichter P, Pfister SM. Biological and clinical heterogeneity of MYCN-amplified medulloblastoma. Acta Neuropathol 123:515-27, 2011
Ramaswamy V, Northcott PA, Taylor MD. FISH and Chips: The recipe for improved prognostication and outcomes for children with medulloblastoma. Cancer Genetics 2011. 204(11), 577-88
Sheng, H., Tse, H. M., Jung, J. Y., Zhang, Z., Spasojevic, I., Piganelli, J., Batinic-Haberle, I., Warner, D. S., Neuroprotective Efficacy From Parenteral Administration of a Redox-Modulating lipophilic MnPorphyrin, MnTHex-2-PyP5+, J Pharmacol. Exp. Ther. 2011, 338, 906-916, PMID: 21652782.
Sanai N, Nguyen T, Ihrie RA, Mirzadeh Z, Tsai HH, Wong M, Gupta N, Berger MS, Huang E, Garcia-Verdugo JM, Rowitch DH, Alvarez-Buylla A. Corridors of migrating neurons in the human brain and their decline during infancy. Nature 478:382-6, 2011
Northcott PA, Shih DJH, Remke M, Cho YJ, Kool M, Hawkins C, Eberhart CG, Dubuc A, Guettouche T, Cardentey Y, Bouffet E, Pomeroy SL, Malkin DM, Rutka JT, Korshunov A, Pfister S, Taylor MD. Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples. Published online, Acta Neuropathologica 2011, November.
Taylor MD, Northcott PA, Korshunov A, Remke M, Yoon-Jae C, Clifford SC, Eberhart CG, Parsons W, Rutkowksi S, Gajjar A, Ellison DW, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM. Molecular Subgroups of Medulloblastoma: The Current Consensus. Acta Neuropathologica, Published online December 2011.
Xiaochong Wu, Paul A. Northcott, Adrian Dubuc, Adam J. Dupuy, Livia Garzia, Charles Eberhart, Hendrik Witt, Timothy Van Meter, David Zagzag, Sid Croul, Todd E. Scheetz, Stefan Pfister, Andrey Korshunov, Eric Bouffet, Stephen W. Scherer, Yoon-Jae Cho, Keiko Akagi, Tobey McDonald, Jan Koster, Aaron L. Sarver, V. Peter Collins, William A. Weiss, David Largaespada, Lara Collier, Michael D. Taylor. 2011. Disseminated medulloblastoma is bicompartmental secondary to clonal selection. Nature. 2012. DOI: 10.1038/nature10825
Dubuc AM, Kloosterhof NK, Yu EP, Northcott PA, Grajkowska W, Van Meter T, Eberhart CG, Pfister SP, Weiss WA, Scherer SW, Rutka JT, French PJ, Taylor MD. Subgroup Specific Alternative Splicing and Promoter Usage in Medulloblastoma. Acta Neuropathologica, Published online February 2012.
Onvani S, Terakawa Y, Smith C, Northcott P, Taylor M, Rutka J. Molecular Genetic Analysis of the Hepatocyte Growth Factor/MET Signaling Pathway in Pediatric Medulloblastoma. Genes, Chromosomes, and Cancer, in press 2012
Li M, Lockwood W, Zielenska M, Northcott P, Shing Ra Y, Bouffet E, Yashimoto M, Rutka JT, Yan H, Taylor MD, Eberhart C, Hawkins CE, Lam W, Squire JA, Huang A. Mutiple CDK/CYCLIND genes are amplified in medulloblastoma and supra-tentorial primitive neuro-ectodermal brain tumors. In press, Cancer Genetics.
